Article
Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients.
Transplant immunology - 1 Oct 2005
Marín L A, Moya-Quiles M R, Miras M, Muro M, Minguela A, Bermejo J, Ramírez P, García-Alonso A M, Parrilla P, Alvarez-López M R
Abstract excerpt
BACKGROUND: Efficient T cell-APC interaction requires the participation of primary and co-stimulatory signals. The main co-stimulatory pathway involves the interaction of CD80 and CD86, expressed on the APCs, with their T cell counter-receptor, CD28 and CTLA-4. Recently, a G to A transition has been described at position +1057 of the CD86 gene, located in their cytoplasmic tail. METHODS: CD86 polymorphism was...
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