Article
Genetic polymorphisms of immunoregulatory proteins in acute renal allograft rejection.
Transplantation proceedings - 1 Oct 2009
Krichen H, Sfar I, Jendoubi-Ayed S, Makhlouf M, Ben Rhomdhane T, Bardi R, Aouadi H, Ben Abdallah T, Ayed K, Gorgi Y
Abstract excerpt
CTLA-4 and CD28 are T lymphocyte receptors involved in the regulation of T-cell activation. Allograft rejection is an alloimune response which is strongly dependent on T-cell proliferation. Thus, we examined the relationship between CTLA-4 and CD28 gene polymorphisms and renal transplant outcomes. We genotyped 141 renal recipients and 229 healthy controls using PCR-SSP methods for the (-318) C/T polymorphism in...
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