Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myostatin blockade improves function but not histopathology in a murine model of limb‐girdle muscular dystrophy 2C

26 Nov 2007

Abstract excerpt

Myostatin is a negative regulator of skeletal muscle growth. Myostatin mutations and pharmacological strategies increase muscle mass in vivo, suggesting that myostatin blockade may prove useful in diseases characterized by muscle wasting, such as the muscular dystrophies. We subjected the gamma-sarcoglycan-deficient (Sgcg(-/-)) mouse model of limb-girdle muscular dystrophy (LGMD) 2C to antibody-mediated myostatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle Physiology and Disorders
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18041051
DOI: 10.1002/mus.20920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myostatin blockade improves function but not histopathology in a murine model of limb‐girdle muscular dystrophy 2CPMID 18041051Read ↗

Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy.Semantic proximity Read ↗

Therapeutic applications and challenges in myostatin inhibition for enhanced skeletal muscle mass and functionsSemantic proximity Read ↗

The elusive promise of myostatin inhibition for muscular dystrophy.Semantic proximity Read ↗

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitorsSemantic proximity Read ↗

[Myostatin blockade therapy for muscular atrophy].Semantic proximity Read ↗

Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects.Semantic proximity Read ↗

Functional characteristics of dystrophic skeletal muscle: insights from animal modelsSemantic proximity Read ↗

Lack of myostatin results in excessive muscle growth but impaired force generationSemantic proximity Read ↗

Myostatin: a modulator of skeletal-muscle stem cellsSemantic proximity Read ↗

AAV-mediated delivery of a mutated myostatin propeptide ameliorates calpain 3 but not alpha-sarcoglycan deficiency.Semantic proximity Read ↗

Morphology and myofiber composition of skeletal musculature of the forelimb in young and aged wild type and myostatin null mice.Semantic proximity Read ↗

Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.