Article
The elusive promise of myostatin inhibition for muscular dystrophy.
Current opinion in neurology - 1 Oct 2020
Wagner Kathryn R
Abstract excerpt
PURPOSE OF REVIEW: Recent terminations of clinical trials of myostatin inhibitors in muscular dystrophy have raised questions about the predictiveness of mouse models for this therapeutic strategy. RECENT FINDINGS: A variety of myostatin inhibitors have been developed for preclinical and clinical studies. These inhibitors have ameliorated the phenotype of many but not all mouse models of muscular dystrophy....
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