Article
The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha.
Clinical endocrinology - 1 Jul 2008
Osawa Haruhiko, Yamada Kazuya, Tabara Yasuharu, Ochi Masaaki, Onuma Hiroshi, Nishida Wataru, Shimizu Ikki, Kawamoto Ryuichi, Fujii Yasuhisa, Miki Tetsuro, Ohashi Jun, Makino Hideichi
Abstract excerpt
OBJECTIVE: The c-Jun N-terminal kinase 1 (JNK1, mitogen-activated kinase 8; MAPK8) phosphorylates insulin receptor substrate-1 (IRS-1) at serine 307, which induces insulin resistance. MAPK8 activity is increased in obese insulin-resistant mice, whereas mapk8 (-/-) mice show decreased adiposity and improved insulin sensitivity. The aim of this study was to determine the relationship between single nucleotide...
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