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Article

Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.

PloS one - 1 Jan 2012

Sartorius Tina, Staiger Harald, Ketterer Caroline, Heni Martin, Machicao Fausto, Guilherme Adilson, Grallert Harald, Schulze Matthias B, Boeing Heiner, Stefan Norbert, Fritsche Andreas, Czech Michael P, Häring Hans-Ulrich

Abstract excerpt

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is expressed in all diabetes-relevant tissues and mediates cytokine-induced insulin resistance. We investigated whether common single nucleotide polymorphisms (SNPs) in the MAP4K4 locus associate with glucose intolerance, insulin resistance, impaired insulin release, or elevated plasma cytokines. The best hit was tested for association with type 2...

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Identifiers

PMID: 23094072
DOI: 10.1371/journal.pone.0047647
PMCID: PMC3475716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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