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Article

The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai.

Journal of human genetics - 1 Jan 2006

Gu Yanyun, Luo Tianhong, Yang Jian, Zhang Di, Dai Meng, Jian Weixia, Zheng Sheng, Zhou Wenzhong, Zhou Weibin, Wu Yixing, Liu Yun, Liu Youping, Li Jiping, Xie Xiaoyan, Li Guo, Luo Min

Abstract excerpt

MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5), an early component of MAP kinase signal cascades was shown to activate Jun kinase in mammalian cells. The association between SNPs of MAP4K5 and type 2 diabetes (T2DM) was investigated due to the known relationship of the JNK pathway with T2DM. A total of 1,399 cases were included in the study. Oral glucose tolerance test (OGTT) and insulin release...

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Identifiers

PMID: 16699725
DOI: 10.1007/s10038-006-0402-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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