Article
The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy.
Journal of the American Society of Nephrology : JASN - 1 Apr 2006
Menzaghi Claudia, Paroni Giulia, De Bonis Concetta, Soccio Teresa, Marucci Antonella, Bacci Simonetta, Trischitta Vincenzo
Abstract excerpt
Inhibiting Galpha subunit 2 protein, which is encoded by the GNAI2 gene, is suggested to be pathogenic for essential hypertension and/or insulin resistance. The aim of this study was to determine whether GNAI2 variations modulate the risk for these abnormalities. Seven single-nucleotide polymorph...
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