Article
[Promoter methylation and microsatellite mutation reveals the clonal relationship of multiple urothelial carcinomas with mutator phenotype].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2005
Stöhr R, Catto J W F, Azzouzi A, Rehmann I, Feeley K, Meuth M, Hamdy F, Burger M, Hartmann A
Abstract excerpt
AIMS: The clonality of multiple urothelial carcinomas (UC) is subject to debate and affects treatment. Evidence derived from X-chromosome mosaicism and patterns of molecular alterations supports both a mono- and polyclonal relationship. In contrast to most UC, tumours with the mutator phenotype have frequent mutations in repetitive sequences (MSI) and promoter methylation. The aim of this study was to investigate...
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