Article
[Promoter methylation and microsatellite mutation reveals the clonal relationship of multiple urothelial carcinomas with mutator phenotype].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2005
Stöhr R, Catto J W F, Azzouzi A, Rehmann I, Feeley K, Meuth M, Hamdy F, Burger M, Hartmann A
Abstract excerpt
AIMS: The clonality of multiple urothelial carcinomas (UC) is subject to debate and affects treatment. Evidence derived from X-chromosome mosaicism and patterns of molecular alterations supports both a mono- and polyclonal relationship. In contrast to most UC, tumours with the mutator phenotype h...
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