The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder.

doi:10.1002/ijc.33327

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Article

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder.

International journal of cancer - 15 Feb 2021

van Doeveren Thomas, Nakauma-Gonzalez Jose A, Mason Andrew S, van Leenders Geert J L H, Zuiverloon Tahlita C M, Zwarthoff Ellen C, Meijssen Isabelle C, van der Made Angelique C, van der Heijden Antoine G, Hendricksen Kees, van Rhijn Bas W G, Voskuilen Charlotte S, van Riet Job, Dinjens Winand N M, Dubbink Hendrikus J, van de Werken Harmen J G, Boormans Joost L

Abstract excerpt

The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed...

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PMID: 33006377
DOI: 10.1002/ijc.33327
PMCID: PMC7821318

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