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Article

Low frequency stimulation decreases seizure activity in a mutation model of epilepsy.

Epilepsia - 1 Sept 2010

Kile Kara Buehrer, Tian Nan, Durand Dominique M

Abstract excerpt

PURPOSE: To investigate brain electrical activity in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene, and to evaluate the efficacy of low frequency deep brain stimulation (DBS) for seizure frequency reduction. METHODS: Electroencephalography (EEG), electromyography (EMG), and hippocampal deep electrodes were implanted into Q54 mice expressing an...

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Identifiers

PMID: 20659150
DOI: 10.1111/j.1528-1167.2010.02679.x
PMCID: PMC3569726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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