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Article

CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers.

Journal of gastroenterology and hepatology - 1 Dec 2007

Hadinia Abolghasem, Hossieni Seyed Vahid, Erfani Nasrollah, Saberi-Firozi Mehdi, Fattahi Mohammad Javad, Ghaderi Abbas

Abstract excerpt

BACKGROUND AND AIM: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by down-regulating T-cell activation. Effects of several polymorphisms in CTLA-4 on CTLA-4 expression and function have been previously documented. The aim of this study was to investigate the putative effect of CTLA-4 polymorphisms on susceptibility to gastric and colorectal...

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Source

Identifiers

PMID: 18031393
DOI: 10.1111/j.1440-1746.2007.04862.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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