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Article

Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer.

Cancer research - 1 Sept 2008

Sun Tong, Zhou Yifeng, Yang Ming, Hu Zhibin, Tan Wen, Han Xiaohong, Shi Yuankai, Yao Jiarui, Guo Yongli, Yu Dianke, Tian Tian, Zhou Xiaoyi, Shen Hongbing, Lin Dongxin

Abstract excerpt

Antitumor T lymphocytes play a pivotal role in immunosurveillance of malignancy. The CTL antigen 4 (CTLA-4) is a vital negative regulator of T-cell activation and proliferation. This study examined whether genetic polymorphisms in CTLA-4 are associated with cancer susceptibility. A two-stage investigation using haplotype-tagging single nucleotide polymorphism approach and multiple independent case-control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18757416
DOI: 10.1158/0008-5472.CAN-08-0806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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