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Article

Association of CTLA-4 gene polymorphisms with sporadic breast cancer risk and clinical features in Han women of northeast China.

Molecular and cellular biochemistry - 1 May 2012

Li Dalin, Zhang Qiujin, Xu Fengyan, Fu Zhenkun, Yuan Weiguang, Li Dianjun, Pang Da

Abstract excerpt

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that plays a pivotal role in downregulating T-cell mediated immune responses. To determine the role of CTLA-4 in tumor immunity, and to validate previous results as well, we investigated four tag single nucleotide polymorphisms (SNPs) of CTLA-4 in a relatively large Chinese Han cohort from northeastern China. Genotypes were determined by...

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PMID: 22249287
DOI: 10.1007/s11010-012-1228-8

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