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Article

Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer.

International journal of immunogenetics - 1 Aug 2008

Dilmec F, Ozgonul A, Uzunkoy A, Akkafa F

Abstract excerpt

Colorectal cancer (CRC), also called colon cancer or bowel cancer, includes cancerous growths in the colon, rectum and appendix. The immune system is an important defence mechanism against cancer and is often dysfunctional in patients with malignancies. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and CD28 genes encode receptors that provide negative and positive signals, respectively. Polymorphisms in...

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Source

Identifiers

PMID: 18680513
DOI: 10.1111/j.1744-313X.2008.00782.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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