Article
[Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis].
Zhonghua nei ke za zhi - 1 Jun 2006
Zhou Feng, Xia Bing, Guo Qiu-sha, Wang Qi, Li Lan, Jiang Li, Cheng Hong
Abstract excerpt
OBJECTIVE: Inflammatory bowel disease (IBD) is characterized by the T-cell excessive activation of intestinal mucosa. Cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) is a negative regulator of T-lymphocyte activation. The aim of the present study is to investigate the association between CTLA-4 promoter -1722 (T/C), -1661 (A/G) polymorphisms and ulcerative colitis (UC) in Han Chinese, in Hubei province of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
