Article
Association of cytotoxic T lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer.
Molecular biology reports - 1 Jan 2010
Hou Ruiping, Cao Bangwei, Chen Zhongdong, Li Yong, Ning Tao, Li Chunhui, Xu Changqing, Chen Ziping
Abstract excerpt
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was widely accepted as a pivotal molecule in downregulating T-cell mediated immune responses. In this study we investigated the polymorphisms which would impact the CTLA-4 gene expression and function to assess the association with the risk of gastric cancer. 205 gastric cancer patients and 262 healthy controls were included in the case-control study. PCR and...
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