Article
IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.
Inflammatory bowel diseases - 1 May 2007
Dubinsky Marla C, Wang Dai, Picornell Yoana, Wrobel Iwona, Katzir Lirona, Quiros Antonio, Dutridge Debra, Wahbeh Ghassan, Silber Gary, Bahar Ron, Mengesha Emebet, Targan Stephan R, Taylor Kent D, Rotter Jerome I
Abstract excerpt
BACKGROUND: The IL-23 receptor (IL-23R) has been found to be associated with small bowel Crohn's disease (CD) in a whole genome association study. Specifically, the rare allele of the R381Q single nucleotide polymorphism (SNP) conferred protection against CD. It is unknown whether IL-23R is associated with IBD in children. The aim was to examine the association of IL-23R with susceptibility to IBD in pediatric...
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