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Article

Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children.

The American journal of gastroenterology - 1 Mar 2008

Amre Devendra K, Mack David, Israel David, Morgan Kenneth, Lambrette Philippe, Law Liliane, Grimard Guy, Deslandres Colette, Krupoves Alfreda, Bucionis Vytautas, Costea Irina, Bissonauth Vishnee, Feguery Houda, D'Souza Savio, Levy Emile, Seidman Ernest G

Abstract excerpt

BACKGROUND AND OBJECTIVES: Interleukin (IL)-23 is a key regulator of inflammation and influences the activities of T-helper 17 (Th-17) lymphocytes. Recent reports indicate that variants in the gene coding for its receptor (IL-23R) are strongly associated with Crohn's disease (CD). We investigated whether DNA variants in the IL-23R gene determine susceptibility for CD in Canadian children. DESIGN AND METHODS: A...

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Identifiers

PMID: 18047539
DOI: 10.1111/j.1572-0241.2007.01661.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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