Article
NAT2 and NER genetic variants and sporadic prostate cancer susceptibility in African Americans.
Prostate cancer and prostatic diseases - 1 Jan 2008
Hooker S, Bonilla C, Akereyeni F, Ahaghotu C, Kittles R A
Abstract excerpt
Prostate cancer is a common malignancy that disproportionately affects African-American men. Environmental factors and variation in genes responsible for chemical and dietary carcinogen metabolism and DNA damage repair may modulate risk. Fourteen single nucleotide polymorphisms in NAT2 and four NER genes (ERCC1, XPF/ERCC4, XPG/ERCC5 and CSB/ERCC6) were genotyped in a case-control study of 254 African-American...
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