Article
Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study.
Neurology - 20 Nov 2007
Bäumer T, Pramstaller P P, Siebner H R, Schippling S, Hagenah J, Peller M, Gerloff C, Klein C, Münchau A
Abstract excerpt
BACKGROUND: In patients with Parkinson disease (PD), transcranial magnetic stimulation (TMS) studies have consistently demonstrated a reduced inhibitory tone in the sensorimotor cortex. It remains unclear whether this is related to motor symptoms or represents adaptive compensatory changes to degeneration of dopaminergic neurons. Here we used short-interval afferent inhibition after digital stimulation (dSAI) and...
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