Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Motor cortical physiology in patients and asymptomatic carriers of parkin gene mutations.

Movement disorders : official journal of the Movement Disorder Society - 15 Oct 2008

Schneider Susanne A, Talelli Penelope, Cheeran Binith J, Khan Naheed L, Wood Nicholas W, Rothwell John C, Bhatia Kailash P

Abstract excerpt

Autosomal recessive parkin (PARK2) gene-related parkinsonism may be phenotypically and pathophysiologically distinct from idiopathic Parkinson's disease (PD). Furthermore, asymptomatic subjects carrying a single parkin mutation ("parkin carriers") may show striatal dopaminergic dysfunction and increased cortical movement-related activation. Here, we used transcranial magnetic stimulation (TMS) to study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electric Stimulation
Share to Electromyography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Motor

Share to Motor Cortex

Share to Neural Conduction

Share to Pyramidal Tracts

Share to Sensory Thresholds

Share to Transcranial Magnetic Stimulation

Source

Identifiers

PMID: 18759365
DOI: 10.1002/mds.22025

Genes

AMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Motor cortical physiology in patients and asymptomatic carriers of parkin gene mutations.PMID 18759365Read ↗

Abnormal premotor-motor interaction in heterozygous Parkin- and Pink1 mutation carriers.Semantic proximity Read ↗

Neurophysiological evaluation of motor corticospinal pathways by TMS in idiopathic early-onset Parkinson's disease.Semantic proximity Read ↗

Motor pathway excitability in ATP13A2 mutation carriers: a transcranial magnetic stimulation study.Semantic proximity Read ↗

Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism.Semantic proximity Read ↗

Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study.Semantic proximity Read ↗

The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study.Semantic proximity Read ↗

Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations.Semantic proximity Read ↗

Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson's disease.Semantic proximity Read ↗

Cortical Function in Asymptomatic Carriers and Patients With<i>C9orf72</i>Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism.Semantic proximity Read ↗

Transcranial alternating current stimulation for Parkinson's disease: a systematic review and meta-analysis of motor outcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.