Article
Impaired intracortical inhibition demonstrated in vivo in people with Dravet syndrome.
Neurology - 25 Apr 2017
Stern William M, Sander Josemir W, Rothwell John C, Sisodiya Sanjay M
Abstract excerpt
OBJECTIVE: Dravet syndrome is a rare neurodevelopmental disorder characterized by seizures and other neurologic problems. SCN1A mutations account for ∼80% of cases. Animal studies have implicated mutation-related dysregulated cortical inhibitory networks in its pathophysiology. We investigated such networks in people with the condition. METHODS: Transcranial magnetic stimulation using single and paired pulse...
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