Multiple primary melanomas in a CDKN2A mutation carrier exposed to ionizing radiation.

doi:10.1001/archderm.143.11.1409

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Article

Multiple primary melanomas in a CDKN2A mutation carrier exposed to ionizing radiation.

Archives of dermatology - 1 Nov 2007

Eliason Mark J, Hansen Chris B, Hart Marybeth, Porter-Gill Patricia, Chen Wei, Sturm Richard A, Bowen Glen, Florell Scott R, Harris Ronald M, Cannon-Albright Lisa A, Swinyer Leonard, Leachman Sancy A

Abstract excerpt

BACKGROUND: Recent research has shown a possible causal relationship between ionizing radiation exposure and melanoma. Individuals with mutations in CDKN2A (cyclin-dependent kinase inhibitor 2A), the major melanoma predisposition gene, have an increased susceptibility to melanoma-promoting exposures, such as UV light. We describe a patient from a familial melanoma pedigree with 7 primary melanomas on the right...

Topics

5' Untranslated Regions
Adult
Arginine
Cysteine
Environmental Exposure
Female
Genes, p16
Genetic Predisposition to Disease
Hair Color
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Melanoma

Mutation

Neoplasms, Multiple Primary

Neoplasms, Radiation-Induced

Nuclear Weapons

Receptor, Melanocortin, Type 1

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 18025365
DOI: 10.1001/archderm.143.11.1409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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