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Multiple Primary Melanoma Associated with CDKN2A Mutation-Case Report and Review of the Literature.

Medicina (Kaunas, Lithuania) - 5 May 2024

Nurla Luana-Andreea, Aşchie Mariana, Cozaru Georgeta Camelia, Boșoteanu Mădălina

Abstract excerpt

The CDKN2A gene remains understudied in melanoma compared to BRAF alterations. Inactivation of this tumor suppressor gene through homozygous deletions in the 9p21 chromosomal region leads to cellular proliferation and disrupts pro-apoptotic pathways. Genetic changes in CDKN2A are linked to multiple primary melanomas (MPM), with patients diagnosed with melanoma facing an elevated risk of developing additional...

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Identifiers

PMID: 38792946
DOI: 10.3390/medicina60050763
PMCID: PMC11122717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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