Article
Genetic mutations involved in melanoma: a summary of our current understanding.
Advances in dermatology - 1 Jan 2007
High Whitney A, Robinson William A
Abstract excerpt
The biomolecular understanding of melanoma is in flux. The importance of high-penetrance genes involved in familial melanoma includes a significant number of mutations that directly lead to impairment of the checkpoints of the normal cell cycle. Furthermore, a greater understanding of the interaction between genetic factors and environmental factors, such as MC1R, CDKN2A, BRAF, and ultraviolet light, is emerging...
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