Article
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
Blood - 1 May 2008
Loriaux Marc M, Levine Ross L, Tyner Jeffrey W, Fröhling Stefan, Scholl Claudia, Stoffregen Eric P, Wernig Gerlinde, Erickson Heidi, Eide Christopher A, Berger Roland, Bernard Olivier A, Griffin James D, Stone Richard M, Lee Benjamin, Meyerson Matthew, Heinrich Michael C, Deininger Michael W, Gilliland D Gary, Druker Brian J
Abstract excerpt
To determine whether aberrantly activated tyrosine kinases other than FLT3 and c-KIT contribute to acute myeloid leukemia (AML) pathogenesis, we used high-throughput (HT) DNA sequence ana-lysis to screen exons encoding the activation loop and juxtamembrane domains of 85 tyrosine kinase genes in 188 AML patients without FLT3 or c-KIT mutations. The screen identified 30 nonsynonymous sequence variations in 22...
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