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Article

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo

5 Mar 2011

Abstract excerpt

A transient erythromyeloid wave of definitive hematopoietic progenitors (erythroid/myeloid progenitors [EMPs]) emerges in the yolk sac beginning at embryonic day 8.25 (E8.25) and colonizes the liver by E10.5, before adult-repopulating hematopoietic stem cells. At E11.5, we observe all maturational stages of erythroid precursors in the liver and the first definitive erythrocytes in the circulation. These early...

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PMID: 21378272
DOI: 10.1182/blood-2010-12-325357

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