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Article

A molecular roadmap of definitive erythropoiesis from human induced pluripotent stem cells.

British journal of haematology - 1 Mar 2017

Razaq Muhammad A, Taylor Stephen, Roberts David J, Carpenter Lee

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) are being considered for use in understanding haematopoietic disorders and as a potential source of in vitro manufactured red cells. Here, we show that hiPSCs are able to recapitulate various stages of developmental erythropoiesis. We show that primitive erythroblasts arise first, express CD31+ with CD235a+ , embryonic globins and red cell markers, but fail to express...

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Identifiers

PMID: 28060419
DOI: 10.1111/bjh.14491

Genes

HBB
HBG1
KLF1

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