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Philadelphia Chromosome–Positive Acute Lymphocytic Leukemia: A New Era of Challenges

1 Jan 2007

Abstract excerpt

Significant advances in the treatment of Philadelephia chromosome (Ph)- or BCR-ABL-positive acute lymphocytic leukemia (ALL) have been made since the discovery of the selective ABL tyrosine kinase inhibitors (TKIs). Whereas the outcome with standard chemotherapy was previously dismal, incorporation of imatinib mesylate into frontline therapy has improved relapse-free and overall survival. The benefit of imatinib...

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Identifiers

PMID: 18024662
DOI: 10.1182/asheducation-2007.1.435

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