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Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

22 Feb 2021

Abstract excerpt

fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein. Tyrosine kinase inhibitors (known as TKIs) are the standard therapy for CML and greatly increase the survival rates, despite adverse effects and the odds of residual disease after discontinuation of treatment. As therapeutic...

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PMID: 33680875
DOI: 10.5306/wjco.v12.i2.69

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