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Philadelphia chromosome‐positive acute lymphoblastic leukemia– current concepts and future perspectives

1 Jun 2002

Abstract excerpt

Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) is diagnosed rarely in children, but constitutes the most frequent cytogenetic abnormality in adults with ALL. In contrast to chronic myeloid leukemia (CML), patients with Ph-positive ALL usually demonstrate expression of a truncated version of the BCR-ABL protein called p190bcr-abl. Irrespective of age and breakpoint location, Ph-positive...

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PMID: 12196213
DOI: 10.1046/j.1468-0734.2002.00066.x

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