Article
Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges
23 Apr 2019
Abstract excerpt
The Philadelphia (Ph) chromosome, resulting from the t(9;22)(q34;q11) translocation, can be found in chronic myeloid leukemia (CML) as well as in a subset of acute lymphoblastic leukemias (ALL). The deregulated BCR-ABL1 tyrosine kinase encoded by the fusion gene resulting from the translocation is considered the pathogenetic driver and can be therapeutically targeted. In both CML and Ph-positive (Ph+) ALL,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.