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Article

NAT2 variants are associated with drug-induced liver injury caused by anti-tuberculosis drugs in Indonesian patients with tuberculosis.

Journal of human genetics - 1 Jun 2016

Yuliwulandari Rika, Susilowati Retno Wilujeng, Wicaksono Britanto Dani, Viyati Kencono, Prayuni Kinasih, Razari Intan, Kristin Erna, Syafrizal, Subagyo, Sri Diana Eva, Setiawati Suci, Ariyani Aziza, Mahasirimongkol Surakameth, Yanai Hideki, Mushiroda Taisei, Tokunaga Katsushi

Abstract excerpt

Drug-induced liver injury (DILI) is the most common adverse drug reaction in the treatment of tuberculosis (TB). Several studies showed that patients with TB and the slow-acetylator phenotype caused by NAT2 variants are highly susceptible to DILI caused by anti-TB drugs, hereafter designated AT-DILI. However, the role of NAT2 variants in AT-DILI has never been assessed for an Indonesian population. We recruited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26911349
DOI: 10.1038/jhg.2016.10

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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