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Article

NAT2 polymorphism and clinical factors that increase antituberculosis drug-induced hepatotoxicity.

Pharmacogenomics - 1 Jun 2022

Mohamed Noor Nur Farhana, Salleh Mohd Zaki, Mohd Zim Mohd Arif, Bakar Zamzurina Abu, Fakhruzzaman Noorizhab Mohd Nur, Zakaria Noor Izyani, Lailanor Muhammad Imran, Teh Lay Kek

Abstract excerpt

Aim: Hepatotoxicity is a known adverse effect of antituberculosis drugs. The NAT2 gene polymorphism has been associated with an increased risk of antituberculosis drug-induced hepatotoxicity (ATDIH). Materials & methods: This study investigates the association of NAT2 polymorphism and clinical risk factors that may contribute to the development of ATDIH. The authors sequenced the NAT2 region of 33 tuberculosis...

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Share to Antitubercular Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35615896
DOI: 10.2217/pgs-2022-0022

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