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Article

Development and characterization of a new single cycle vaccine vector in the simian immunodeficiency virus model system.

Virology - 1 Mar 2008

Tang Y, Swanstrom R

Abstract excerpt

We have developed a new single cycle lentiviral vector, SIVsmH4i-SC27.1, as a potential SIV/HIV-1 vaccine candidate. This viral vector is capable of expressing all of the SIV gene products but is limited to one round of infection. The vector was created by mutating 27 codons dispersed among the viral vif, env, and nef genes to block protein function, attenuate viral replication/infectivity, and reduce the ability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18022661
DOI: 10.1016/j.virol.2007.09.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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