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Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements

1 Apr 1999

Abstract excerpt

Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing cells. Although high-titer HIV-1-derived vectors have been produced, concerns regarding safety still exist. Safety concerns arise mainly from the possibility of recombination between transfer and...

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PMID: 10074131
DOI: 10.1128/jvi.73.4.2832-2840.1999

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