Article
Genetic engineering of a modified herpes simplex virus 1 vaccine vector.
Vaccine - 11 May 2009
Liu Xueqiao, Broberg Eeva, Watanabe Daisuke, Dudek Timothy, Deluca Neal, Knipe David M
Abstract excerpt
The herpes simplex virus 1 (HSV-1) d106 mutant virus is a multiple immediate-early gene deletion mutant virus that has been effective as an AIDS vaccine vector in rhesus macaques (Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, et al. Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology...
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