Article
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
Cancer research - 15 Nov 2007
Liontos Michalis, Koutsami Marilena, Sideridou Maria, Evangelou Konstantinos, Kletsas Dimitris, Levy Brynn, Kotsinas Athanassios, Nahum Odelia, Zoumpourlis Vassilis, Kouloukoussa Mirsini, Lygerou Zoi, Taraviras Stavros, Kittas Christos, Bartkova Jirina, Papavassiliou Athanasios G, Bartek Jiri, Halazonetis Thanos D, Gorgoulis Vassilis G
Abstract excerpt
The accurate execution of DNA replication requires a strict control of the replication licensing factors hCdt1 and hCdc6. The role of these key replication molecules in carcinogenesis has not been clarified. To examine how early during cancer development deregulation of these factors occurs, we investigated their status in epithelial lesions covering progressive stages of hyperplasia, dysplasia, and full...
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