Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation.

The Journal of physiology - 15 Jan 2008

Nam Shin Yuen, Lee Ming Kei, Sabapathy Kanaga

Abstract excerpt

Immune-independent diabetes often occurs via pancreatic beta cell dysfunction. However, the role of the tumour suppressor p53 that regulates cellular life and death in multiple tissues, in pancreatic cell death and diabetes has not been clarified. We have therefore utilized an established mouse model for diabetes in which the MHC class I antigen is overexpressed in pancreatic beta cells under the rat insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Diabetes Mellitus, Experimental
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to H-2 Antigens

Share to Histocompatibility Antigens Class I

Share to Insulin-Secreting Cells

Share to Mice, Transgenic

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 18006584
DOI: 10.1113/jphysiol.2007.142612
PMCID: PMC2375583

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation.PMID 18006584Read ↗

Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice.Semantic proximity Read ↗

Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice.Semantic proximity Read ↗

Selective mtDNA mutation accumulation results in beta-cell apoptosis and diabetes development.Semantic proximity Read ↗

Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.Semantic proximity Read ↗

CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell ApoptosisSemantic proximity Read ↗

Mechanisms of β cell death in diabetes: A minor role for CD95Semantic proximity Read ↗

Interferon-gamma increases susceptibility of murine pancreatic beta cells to lysis by allogeneic cytotoxic T lymphocytes.Semantic proximity Read ↗

Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules.Semantic proximity Read ↗

TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.Semantic proximity Read ↗

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.Semantic proximity Read ↗

Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK.Semantic proximity Read ↗

Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.