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Article

Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis.

Biotechnology letters - 1 Apr 2008

Gomes Catarina, Palma Angelina S, Almeida Rui, Regalla Manuela, McCluskey Leo F, Trojanowski John Q, Costa Júlia

Abstract excerpt

The Golgi apparatus (GA) appears disrupted in motor neurons of amyotrophic lateral sclerosis (ALS). Here, mouse motor neuron-like NSC-34 cell lines stably expressing human superoxide dismutase 1 (hSOD1)(wt) and mutant hSOD1(G93A), as an ALS cell model, were constructed. The number of cells with disrupted GA increased from 14% to 34%. Furthermore, NSC-34/hSOD1(G93A) cells showed lower levels of proliferation and...

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Identifiers

PMID: 18004513
DOI: 10.1007/s10529-007-9595-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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