Article
The Golgi apparatus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions.
Acta neuropathologica - 1 Mar 2002
Fujita Yukio, Okamoto Koichi, Sakurai Atsushi, Kusaka Hirofumi, Aizawa Hitoshi, Mihara Ban, Gonatas Nicholas K
Abstract excerpt
The mechanisms of neuronal death in amyotrophic lateral sclerosis (ALS) are not known. A pathological aggregation of cytoplasmic constituents in the form of variety of inclusions may play a role in the pathogenesis of neuronal death. Cytoplasmic basophilic inclusions (BIs) in motor neurons are commonly found in sporadic juvenile ALS. The functional significance of these inclusions is not known, i.e., whether they...
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