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Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death.

Journal of the neurological sciences - 15 Jul 2006

Gonatas Nicholas K, Stieber Anna, Gonatas Jacqueline O

Abstract excerpt

Fragmentation of the neuronal Golgi apparatus (GA) was reported in amyotrophic lateral sclerosis (ALS), corticobasal degeneration, Alzheimer's and Creutzfeldt-Jacob disease, and in spinocerebelar ataxia type 2 (SCA2). In transgenic mice expressing the G93A mutant of Cu/Zn superoxide dismutase (SOD1) of familial ALS (fALS), fragmentation of the GA of spinal cord motor neurons and aggregation of mutant protein were...

Topics

Cell Death
Golgi Apparatus
Humans
Mutation
Nerve Tissue Proteins
Neurodegenerative Diseases
Organelles

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16545397
DOI: 10.1016/j.jns.2006.01.019

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death.PMID 16545397Read ↗

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The Golgi apparatus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions.Semantic proximity Read ↗

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Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis.Semantic proximity Read ↗

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