Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of novel CYP2A61B variants: the CYP2A61B allele is associated with faster in vivo nicotine metabolism.

Clinical pharmacology and therapeutics - 1 Jan 2008

Mwenifumbo J C, Lessov-Schlaggar C N, Zhou Q, Krasnow R E, Swan G E, Benowitz N L, Tyndale R F

Abstract excerpt

Cytochrome P450 2A6 (CYP2A6) is the human enzyme responsible for the majority of nicotine's metabolism. CYP2A6 genetic variants contribute to the interindividual and interethnic variation in nicotine metabolism. We examined the association between the CYP2A6*1B variant and nicotine's in vivo metabolism. Intravenous infusions of deuterium-labeled nicotine were administered to 292 volunteers, 163 of whom were White...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Flanking Region
Share to Cotinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2A6

Share to Deuterium

Share to Glucuronates

Share to Infusions, Intravenous

Share to Nicotine

Share to Nicotinic Agonists

Source

Open in PubMed Open full text

Identifiers

PMID: 17522595
DOI: 10.1038/sj.clpt.6100246
PMCID: PMC2921956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.PMID 17522595Read ↗

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.Semantic proximity Read ↗

Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.Semantic proximity Read ↗

Genetic variability in CYP2A6 and the pharmacokinetics of nicotine.Semantic proximity Read ↗

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.Semantic proximity Read ↗

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.Semantic proximity Read ↗

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.Semantic proximity Read ↗

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo.Semantic proximity Read ↗

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.Semantic proximity Read ↗

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activitySemantic proximity Read ↗

Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics.Semantic proximity Read ↗

Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.Semantic proximity Read ↗

Smoking behavior and related cancers: the role of CYP2A6 polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.