Article
Action potential alternans in LQT3 syndrome: a simulation study.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Jan 2007
Alonso-Atienza Felipe, Requena-Carrión Jesús, Rojo-Alvarez José Luis, Berenfeld Omer, Jalife José
Abstract excerpt
The long QT syndrome type-3 (LQT3) is an inherited cardiac disorder caused by mutations in the sodium channel gene SCN5A. LQT3 has been associated with ventricular arrhythmias and sudden cardiac death, specially at low heart rates. Based on computer simulations and experimental investigations, analysis of the morphology of the Action Potential (AP) has shown that it undergoes early afterdepolarizations (EADs) and...
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