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Article

Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families.

Circulation research - 16 May 2003

Veldkamp Marieke W, Wilders Ronald, Baartscheer Antonius, Zegers Jan G, Bezzina Connie R, Wilde Arthur A M

Abstract excerpt

One variant of the long-QT syndrome (LQT3) is caused by mutations in the human cardiac sodium channel gene. In addition to the characteristic QT prolongation, LQT3 carriers regularly present with bradycardia and sinus pauses. Therefore, we studied the effect of the 1795insD Na+ channel mutation on sinoatrial (SA) pacemaking. The 1795insD channel was previously characterized by the presence of a persistent inward...

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PMID: 12676817
DOI: 10.1161/01.RES.0000069689.09869.A8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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