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Article

Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique.

The Journal of physiology - 15 Jan 2006

Berecki Géza, Zegers Jan G, Bhuiyan Zahurul A, Verkerk Arie O, Wilders Ronald, van Ginneken Antoni C G

Abstract excerpt

Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the 'dynamic action potential clamp' (dAPC) technique to effectively replace the native sodium current (I(Na)) of the Priebe-Beuckelmann human ventricular cell model with wild-type (WT) or...

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Identifiers

PMID: 16254012
DOI: 10.1113/jphysiol.2005.096578
PMCID: PMC1464302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16254012-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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