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Article

Rate-dependent QT shortening mechanism for the LQT3 deltaKPQ mutant.

Cardiovascular research - 1 Jun 2002

Nagatomo Toshihisa, January Craig T, Ye Bin, Abe Haruhiko, Nakashima Yasuhide, Makielski Jonathan C

Abstract excerpt

OBJECTIVE: For the congenital long QT (LQT) syndrome involving mutations of the cardiac sodium channel gene SCN5A, LQT3, the initiation of sudden cardiac death tends to be bradycardia- or pause-dependent, contrary to other LQT syndromes that tend to be adrenergic dependent. Enhanced shortening of the prolonged QT interval with increased heart rate has been reported in LQT3 patients. We hypothesized that the...

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Identifiers

PMID: 12031708
DOI: 10.1016/s0008-6363(02)00265-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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