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Article

CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller.

Retrovirology - 6 Nov 2012

Burwitz Benjamin J, Giraldo-Vela Juan Pablo, Reed Jason, Newman Laura P, Bean Alexander T, Nimityongskul Francesca A, Castrovinci Philip A, Maness Nicholas J, Leon Enrique J, Rudersdorf Richard, Sacha Jonah B

Abstract excerpt

BACKGROUND: Virus-specific T cells are critical components in the containment of immunodeficiency virus infections. While the protective role of CD8+ T cells is well established by studies of CD8+ T cell-mediated viral escape, it remains unknown if CD4+ T cells can also impose sufficient selective pressure on replicating virus to drive the emergence of high-frequency escape variants. Identifying a high frequency...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23131037
DOI: 10.1186/1742-4690-9-91
PMCID: PMC3496649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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