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Article

Coevolutionary networks of splicing cis-regulatory elements.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007

Xiao Xinshu, Wang Zefeng, Jang Minyoung, Burge Christopher B

Abstract excerpt

Accurate and efficient splicing of eukaryotic pre-mRNAs requires recognition by trans-acting factors of a complex array of cis-acting RNA elements. Here, we developed a generalized Bayesian network to model the coevolution of splicing cis elements in diverse eukaryotic taxa. Cross-exon but not cross-intron compensatory interactions between the 5' splice site (5'ss) and 3' splice site (3'ss) were observed in...

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Identifiers

PMID: 17998536
DOI: 10.1073/pnas.0707349104
PMCID: PMC2141820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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